For most people, coffee is the first step toward feeling alive in the morning. But for Bryan Johnson — the billionaire tech entrepreneur known for spending over ₹17 crore ($2 million) a year in pursuit of biological youth — it’s now more than just a morning ritual. It’s a science-backed longevity strategy.
In a recent Instagram post, Johnson cited a study by Tulane University that tracked over 40,000 U.S. adults for a decade, revealing that coffee drinkers had a 16% lower risk of death from any cause and a 31% lower risk of cardiovascular disease compared to non-drinkers. But, he insists, the secret lies in when you drink it.
“Coffee drinkers live longer, but there’s a catch,” Johnson explained in his video. “If you’re drinking coffee in the afternoon to stay awake, you might be losing out on its longevity benefits.”
The science behind coffee’s timing
Caffeine, he explains, has a half-life of about five to six hours in the body. That means your 3 p.m. coffee fix could leave the equivalent of half a cup still circulating in your system at 9 p.m. — disrupting your sleep and, ironically, your body’s recovery process.
“Sleep is the number one thing you can do for your overall health,” Johnson reminded followers, emphasizing that late-day caffeine can quietly sabotage even the healthiest routines.
The Tulane University study adds weight to his claim, showing that morning coffee drinkers benefit most from caffeine’s metabolic and cardiovascular effects, while those who consume it later risk sleep disturbances that counteract those same benefits.
Coffee as a longevity therapy
According to Johnson, coffee consumed early in the day — and without sugar — can “double as a longevity therapy.” The beverage’s polyphenols and caffeine content are said to support the body’s process of autophagy — a natural cellular “cleanup” mechanism that helps recycle damaged cells.
As reported by Tulane University researchers, coffee can also improve vascular function, boost metabolism, and provide anti-inflammatory and neuroprotective benefits. These effects, Johnson says, can collectively help slow the biological aging process.
“When coffee isn’t interrupting your sleep, it boosts metabolic rate, improves blood flow, and triggers autophagy,” Johnson said. “Do caffeine right, and it may also help you live longer.”
The minimalist approach
Johnson, who follows a highly disciplined schedule of eating between 6 a.m. and 11 a.m. and sleeping by 8:30 p.m., had previously sworn off caffeine. But after reviewing Tulane’s findings, he has reintroduced coffee — strategically, only in the morning.
The key, he says, is to avoid sugar-loaded drinks like flavored lattes and to stick to clean, black coffee early in the day.
While Johnson’s broader anti-aging experiments — including plasma transfusions, strict diet plans, and extensive data tracking — often make headlines for their eccentricity, his coffee advice aligns closely with mainstream health science.
In a recent Instagram post, Johnson cited a study by Tulane University that tracked over 40,000 U.S. adults for a decade, revealing that coffee drinkers had a 16% lower risk of death from any cause and a 31% lower risk of cardiovascular disease compared to non-drinkers. But, he insists, the secret lies in when you drink it.
“Coffee drinkers live longer, but there’s a catch,” Johnson explained in his video. “If you’re drinking coffee in the afternoon to stay awake, you might be losing out on its longevity benefits.”
The science behind coffee’s timing
Caffeine, he explains, has a half-life of about five to six hours in the body. That means your 3 p.m. coffee fix could leave the equivalent of half a cup still circulating in your system at 9 p.m. — disrupting your sleep and, ironically, your body’s recovery process.
“Sleep is the number one thing you can do for your overall health,” Johnson reminded followers, emphasizing that late-day caffeine can quietly sabotage even the healthiest routines.
The Tulane University study adds weight to his claim, showing that morning coffee drinkers benefit most from caffeine’s metabolic and cardiovascular effects, while those who consume it later risk sleep disturbances that counteract those same benefits.
Coffee as a longevity therapy
According to Johnson, coffee consumed early in the day — and without sugar — can “double as a longevity therapy.” The beverage’s polyphenols and caffeine content are said to support the body’s process of autophagy — a natural cellular “cleanup” mechanism that helps recycle damaged cells.
As reported by Tulane University researchers, coffee can also improve vascular function, boost metabolism, and provide anti-inflammatory and neuroprotective benefits. These effects, Johnson says, can collectively help slow the biological aging process.
“When coffee isn’t interrupting your sleep, it boosts metabolic rate, improves blood flow, and triggers autophagy,” Johnson said. “Do caffeine right, and it may also help you live longer.”
The minimalist approach
Johnson, who follows a highly disciplined schedule of eating between 6 a.m. and 11 a.m. and sleeping by 8:30 p.m., had previously sworn off caffeine. But after reviewing Tulane’s findings, he has reintroduced coffee — strategically, only in the morning.
The key, he says, is to avoid sugar-loaded drinks like flavored lattes and to stick to clean, black coffee early in the day.
While Johnson’s broader anti-aging experiments — including plasma transfusions, strict diet plans, and extensive data tracking — often make headlines for their eccentricity, his coffee advice aligns closely with mainstream health science.
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